Glen research/Glen UnySupport™ 1000/1kit/20-5241-41
商品编号：
20-5241-41
品牌：
Glenresearch
市场价：
¥1200.00
美元价：
720.00
产品分类：
电生理设备
公司分类：
Electrophysiological
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Technical Documents
Description
Details
Intellectual Property
References
Technical Documents
Description
Our original Universal Support (20-5000) has been discontinued since complete dephosphorylation using ammonium hydroxide, AMA or anhydrous methylamine gas takes longer than most companies wish to allocate.A recent development has been the use of a support based on a molecule which is "conformationally preorganized" to accelerate the dephosphorylation reaction.1,2By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than the original Universal Support.The structure of Glen UnySupport is shown below.The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis.Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection.We are happy to offer Glen UnySupport in a variety of popular formats under license from Isis Pharmaceuticals.
Details
Usage
- Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
- Deprotection: Solution phase:Ammonium Hydroxide:MethylAmine (AMA) 1:1 for 1 hour at 65°C or Ammonium Hydroxide for 8 hours at 55°C. For sensitive minor bases or dyes, Glen UnySupport may be eliminated with 50 mM Potassium Carbonate in Methanol in 17 hours at room temperature or with Tert-Butylamine/water 1:3 (v/v) for 4 hours at 60°C.Gas Phase:Methylamine gas for 30 minutes at 65°C at 30 psi.
| Specifications | |
|---|---|
| Storage | Controlled room temperature or lower, dry |
Intellectual Property
This product is covered by US Patent 7,202,264 owned by Ionis Pharmaceuticals, Inc..
References
REFERENCE(S)| 1 A.P. Guzaev, and M. Manoharan, J Am Chem Soc, 2003, 125, 2380- 2381.| 2 R.K. Kumar, A.P. Guzaev, C. Rentel, and V.T. Ravikumar, Tetrahedron, 2006, 62, 4528.
Related Products
Related Products
Glen UnySupport™ 500Catalog #: 20-5040
High Load Glen UnySupport™Catalog #: 25-5040
Glen UnySupport™ FCCatalog #: 22-5041
Glen UnySupport™ PSCatalog #: 26-5040
Universal Support III PSCatalog #: 26-5010
品牌介绍
Glen research对我们的员工，我们的客户和环境的承诺Maravai LifeSciences致力于在所有业务活动中成为环境，健康与安全（EHS）管理方面的领导者，符合Maravai LifeSciences的商业利益和行为准则。我们承诺：雇员我们将通过提供零伤害的工作场所来预防伤害和疾病并促进健康的生活方式，从而对每位员工产生积极影响。我们将确保我们的员工具有执行此政策的意识，工具和知识。可持续发展我们将通过使用确保安全，效率和社会责任的商业惯例，以现在和将来保护我们的员工，社区，股东和环境的方式，进行可持续思考和采取行动。合规我们将遵守适用的法律和法规，同时提供程序和程序以确保我们的遵守。文化我们将通过停工授权，查明根本原因并采取纠正措施，倡导一种不容忍不安全状况和行为的文化。业务整合我们会将环境，健康和安全考虑因素纳入我们的业务活动。顾客我们将与客户紧密合作，以帮助他们满足其环境，健康和安全需求。供应商和承包商我们将与我们的供应商和承包商合作，以改善环境，健康和安全绩效。社区与政府我们将参与社区和政府的环境，健康和安全计划。这些价值观得到了Maravai高层管理人员的重视，并在组织内的所有责任级别得到强调。卡尔·赫尔（Carl Hull）首席执行官
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